LL - SCS RetroAge

RETROAGE - Healthy Cellular Longevity

• Greater flexibility and strength
• More supple, glowing, youthful-looking skin
• Fewer fine lines and wrinkles
• Decreased inflammation
• DNA protection and repair
• Boosted immunity improved kidney function
• Faster recovery from exercise
• Clearer, sharper vision
• Faster wound healing and softening of scarring
• More energy thanks to improved mitochondrial function
• Increased cardiovascular function due to improved uptake of oxygen
• Clearer, sharper thinking with improved cognitive function.

Features

Q: What are the benefits? Anti-aging, Antioxidant, 

• More energy and stamina
• Better exercise and sports performance
• Sharper, clearer brain function, memory, and cognition
• Plumper skin and less wrinkles
• Better eyesight
• Faster wound healing

Q: What ingredients does it contain? L-Carnosine and Benofotiamine/vitamin B1

Q: What are the ingredients sourced from (Example: What form of Vit C is used?) - both ingredients are synthetic 

Q: Is it free of artificial ingredients, sweeteners, flavors colors, etc?

Q: Is it free of allergens? Yes

Q: Which ingredients are Non-GMO? 

Q: Which ingredients are organic?

Q: Which ingredients are vegetarian or vegan? this product does not contain animal products / suitable for vegans

Q: If any of the ingredients are derived from animal products   - none

Q: What is the capsule made of? - Vegi Capsule (Vegetable Cellulose)

Q: Please describe the process of extraction of the ingredient from its source 

• Is it a chemical or mechanical process?
• What chemicals are used during extraction? 
• Is heat used? 
• Water/alcohol?

Q: Are the ingredients tested for purity? YES, COA ON FILE 

Q: Does this product need refrigeration? NO

Q: What is the expiration date?

Suggested Use

Q: What is the recommended intake? Each capsule of RetroAge contains 450mg of carnosine.

We recommend one capsule, three times a day for a total of 1350 mg--the optimum daily dosage recommended by scientists if you want to fight oxidation and glycation on a daily basis.

Q: What size are the capsules?

Q: How many capsules are in each bottle? 60

Safety

Q: Is this product recommended for people of any age? Healthy adults over age 18

Q: Safety precautions - are there any types of medications that interfere?

Q: I’m pregnant. Is it OK to use this product?

Ingredients: 

L-Carnosine - 450 mg

Sales Page: https://retroage.suncoastsciences.com/

Research Citations: 

• 1. Fournet M, Bonté F, Desmoulière A. Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging. Aging Dis. 2018;9(5):880-900. Published 2018 Oct 1. doi:10.14336/AD.2017.1121
• 2. Prokopieva VD, Yarygina EG, Bokhan NA, Ivanova SA. Use of Carnosine for Oxidative Stress Reduction in Different Pathologies. Oxid Med Cell Longev. 2016;2016:2939087. doi:10.1155/2016/2939087
• 3. Prokopieva VD, Yarygina EG, Bokhan NA, Ivanova SA. Use of Carnosine for Oxidative Stress Reduction in Different Pathologies. Oxid Med Cell Longev. 2016;2016:2939087. doi:10.1155/2016/2939087
• 4. Wu G. Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health. Amino Acids. 2020;52(3):329-360. doi:10.1007/s00726-020-02823-6
• 5. Ilipkiss A. Carnosine. a protective, anti-ageing peptide? Int J Biochem Cell Biol. 1998, 30: S63- 868. 
• 6. Fournet M, Bonté F, Desmoulière A. Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging. Aging Dis. 2018;9(5):880-900. Published 2018 Oct 1. doi:10.14336/AD.2017.1121
• 7. Waris G, Ahsan H. Reactive oxygen species: role in the development of cancer and various chronic conditions. J Carcinog. 2006;5:14. Published 2006 May 11. doi:10.1186/1477-3163-5-14
• 8. Quinn PL Boldyrev AA. Formaziuk VH. Carnosine: its properties, functions and potential therapeutic applications. Mol Aspects Mod, 1992, 13(5):379-444
• 9. Boldyrev, A.A. Carnosine: New concept for the function of an old molecule. Biochemistry Moscow 77, 313–326 (2012). https://doi.org/10.1134/S0006297912040013
• 10. Cararo JH, Streck EL, Schuck PF, Ferreira Gda C. Carnosine and Related Peptides: Therapeutic Potential in Age-Related Disorders. Aging Dis. 2015;6(5):369-379. Published 2015 Oct 1. doi:10.14336/AD.2015.0616
• 11. Fournet M, Bonté F, Desmoulière A. Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging. Aging Dis. 2018;9(5):880-900. Published 2018 Oct 1. doi:10.14336/AD.2017.1121
• 12. Bierhaus A, Hofmann MA, Ziegler R, et al. AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept. Cardiovascular Research. 1998; 37(3):586-600.
• 13. Munch G, Schinzel R, Loske C, et al. Alzheimer's disease-synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts. Journal of Neural Transmission. 1998; 105(4-5):439-61.
• 14. Freund, M.A., Chen, B. and Decker, E.A. (2018), The Inhibition of Advanced Glycation End Products by Carnosine and Other Natural Dipeptides to Reduce Diabetic and Age-Related Complications. Comprehensive Reviews in Food Science and Food Safety, 17: 1367-1378. https://doi.org/10.1111/1541-4337.12376
• 15. Alan R Hipkiss, Carnosine, a protective, anti-ageing peptide?, The International Journal of Biochemistry & Cell Biology, Volume 30, Issue 8, 1998, Pages 863-868, ISSN 1357-2725, https://doi.org/10.1016/S1357-2725(98)00060-0.
• 16. Culbertson JY, Kreider RB, Greenwood M, Cooke M. Effects of beta-alanine on muscle carnosine and exercise performance: a review of the current literature. Nutrients. 2010;2(1):75-98. doi:10.3390/nu2010075
• 17. McFarlandGA, HollidayR. Further evidence for the rejuvenating effects of the dipeptide I .- carnosine on cultured human diploid fibroblast. Exp Gerontol 1999 34(l):35-45
• 18. Tsunenaga, Makoto Anti-aging and anti-wrinkle effects of the natural anti-oxidant carnosineFragrance Journal = Fragrance journal v.36 no.2 , 2008 ?, pp.55 --62
• 19. Caruso, Giuseppe; Fresta, Claudia G.; Grasso, Margherita; Santangelo, Rosa; Lazzarino, Giuseppe; Lunte, Susan M.; Caraci, Filippo; Inflammation as the Common Biological Link Between Depression and Cardiovascular Diseases: Can Carnosine Exert a Protective Role? Current Medicinal Chemistry, Volume 27, Number 11, 2020, pp. 1782-1800(19) https://doi.org/10.2174/0929867326666190712091515
• 20. Paul Hyland, Orla Duggan, Alan Hipkiss, Christopher Barnett, Yvonne Barnett,The effects of carnosine on oxidative DNA damage levels and in vitro lifespan in human peripheral blood derived CD4+T cell clones, Mechanisms of Ageing and Development, Volume 121, Issues 1–3, 2001, Pages 203-215, ISSN 0047-6374,https://doi.org/10.1016/S0047-6374(00)00211-6.
• 21. Wu G. Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health. Amino Acids. 2020;52(3):329-360. doi:10.1007/s00726-020-02823-6
• 22. Kawther M. Soliman, Manal Abdul-Hamid, Amel I. Othman; Effect of carnosine on gentamicin-induced nephrotoxicity, Med Sci Monit 2007; 13(3): BR73-83 ID: 475524,2007-03-0
• 23. Sale C, Artioli GG, Gualano B, Saunders B, Hobson RM, Harris RC. Carnosine: from exercise performance to health. Amino Acids. 2013 Jun;44(6):1477-91. doi: 10.1007/s00726-013-1476-2. Epub 2013 Mar 12. PMID: 23479117.
• 24. Hill C A, et al., 2007. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. J Amino Acids, 32: 225−233.
• 25. 10) Maichuk luF, Formaziuk VF. Sergienku VI. Development of carnosine eye drops and assessing their efficiency in corneal diseases. Vestn Oftalmol 1997.1 13(ft);27-31. 
• 26. Roberts PR, Black KW, Santamauro JT. Dietary peptides improve wound healing following surgery. Nutrition, 1998, 14(3):26h-2^9. 
• 27. Nagai K, Suda T, Kawasaki K, et al. Action of carnosine and beta-alanine on wound healing. Surgery. 1986;100(5):815-21.
• 28. Zhao Dai, Xin-Yi Lu, Wen-Li Zhu, Xiao-Qi Liu, Ben-Yue Li,abc Lei Song,abc Hao-Fei Liu,abc Wei-Wu Cai,abc Ya-Xiang Deng,abc Ting-Ting Xu,abc Qi Wang*abc and Shi-Jie Zhang; Carnosine ameliorates age-related dementia via improving mitochondrial dysfunction in SAMP8 mice; Food and Function Journal, Issue #3, 2020
• 29. Roberts PR, Zaloga GP. Cardiovascular effects of carnosine. Biochemistry (Mosc). 2000 Jul;65(7):856-61. PMID: 10951105.
• 30. Preston J et al. Toxic effects of B-amyloid on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and B-alanine. Neuroscience letters 1998, 242; 105-108.
• 31. McFarland GA, Holliday R. Retardation of the senescence of cultured human diploid fibroblasts by carnosine. Exp Cell Res. 1994; 212(2):167-75.
• 32. Brownson C, Hipkiss AR. Carnosine reacts with a glycated protein. Free Radic Biol Med. 2000; 28(10):1564-70.
• 33. Tallon MJ et al. “Carnosine, taurine and enzyme activities of human skeletal muscle fibres from elderly subjects with osteoarthritis and young moderately active subjects.” Biogerontology. 2007;8(2):129-37.
• 34. Xia-Qing Wu, Dan-Dan Zhang, Yan-Ni Wang, Yue-Qi Tan, Xiao-Yong Yu, Ying-Yong Zhao, AGE/RAGE in diabetic kidney disease and ageing kidney, Free Radical Biology and Medicine, 10.1016/j.freeradbiomed.2021.05.025, 171, (260-271), (2021).
• 35. Wu G. Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health. Amino Acids. 2020;52(3):329-360. doi:10.1007/s00726-020-02823-6
• 36. Nagai K, Suda T. [Immuno-enhancing actions of carnosine and homocarnosine]. Nihon Seirigaku zasshi. Journal of the Physiological Society of Japan. 1986 ;48(11):735-740.
• 37. Schön M, Mousa A, Berk M, et al. The Potential of Carnosine in Brain-Related Disorders: A Comprehensive Review of Current Evidence. Nutrients. 2019;11(6):1196. Published 2019 May 28. doi:10.3390/nu11061196
• 38. Schon, Martin & Mousa, Aya & Berk, Michael & Chia, Wern Li & Ukropec, Jozef & Majid, Arshad & Ukropcova, Barbara & De Courten, Barbora. (2019). The Potential of Carnosine in Brain-Related Disorders: A Comprehensive Review of Current Evidence. Nutrients. 11. 10.3390/nu11061196. 
• 39. Stout JR, et al., 2006. Effects of twenty-eight days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold. J Strngth & Cond Resrch, 20(4) : 928−931.
• 40. Van Thienen R, et al., 2009. Beta-alanine improves sprint performance in endurance cycling. Med. Sci. Sports Exerc. 41: 898–903
• 41. Guaitolini E, Cavezzi A, Cocchi S, Colucci R, Urso SU, Quinzi V. Randomized, Placebo-controlled Study of a Nutraceutical Based on Hyaluronic Acid, L-carnosine, and Methylsulfonylmethane in Facial Skin Aesthetics and Well-being. J Clin Aesthet Dermatol. 2019;12(4):40-45.
• 42. Tsunenaga, Makoto; Anti-aging and anti-wrinkle effects of the natural anti-oxidant carnosine Fragrance Journal = Fragrance journal v.36 no.2 , 2008, pp.55--62
• 43. Alkhalaf A, Kleefstra N, Groenier KH, et al. Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy. PLoS One. 2012;7(7):e40427. doi:10.1371/journal.pone.0040427
• 44. Hipkiss A.R., « Carnosine, a protective anti-aging peptide? », Int. Biochem. Cell. Biol., 1998, 30(8):863-8.
• 45. Roberts PR, Zaloga GP. Cardiovascular effects of carnosine. Biochemistry (Mosc). 2000 Jul;65(7):856-61. PMID: 10951105.
• 46. Stout JR, et al., 2006. Effects of twenty-eight days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold. J Strngth & Cond Resrch, 20(4) : 928−931.
• 47. Schön M, Mousa A, Berk M, et al. The Potential of Carnosine in Brain-Related Disorders: A Comprehensive Review of Current Evidence. Nutrients. 2019;11(6):1196. Published 2019 May 28. doi:10.3390/nu11061196
• 48. Atwood CS, Moir RD, Huang X, et al. Dramatic aggregation of Alzheimer Ab by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem. 1998; 273(21):12817-26.
• 49. Tsunenaga, Makoto; Anti-aging and anti-wrinkle effects of the natural anti-oxidant carnosine Fragrance Journal = Fragrance journal v.36 no.2 , 2008, pp.55--62
• 50. Nagai K, Suda T, Kawasaki K, et al. Action of carnosine and beta-alanine on wound healing. Surgery. 1986;100(5):815-21.